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1

Strategies and challenges for the next generation of antibody–drug conjugates

Beck, Alain, Goetsch, Liliane, Dumontet, Charles, Corvaïa, Nathalie

Journal:

Nature Reviews Drug Discovery

Year:

2017

Language:

english

File:

PDF, 1.21 MB

english, 2017

2

Strategies and challenges for the next generation of therapeutic antibodies

Beck, Alain, Wurch, Thierry, Bailly, Christian, Corvaia, Nathalie

Journal:

Nature Reviews Immunology

Year:

2010

Language:

english

File:

PDF, 364 KB

english, 2010

3

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

Beck, Alain, Wagner-Rousset, Elsa, Bussat, Marie-Claire, Lokteff, Maryline, Klinguer-Hamour, Christine, Haeuw, Jean-François, Goetsch, Liliane, Wurch, Thierry, Dorsselaer, Alain, Corvaia, Nathalie

Journal:

Current Pharmaceutical Biotechnology

Year:

2008

Language:

english

File:

PDF, 989 KB

english, 2008

4

SUPPORTS AND PACKAGING FOR MUSEUM OBJECTS IN TRAVELLING EXHIBITIONS

Corvaia, Carmela

Journal:

Year:

1989

Language:

english

File:

PDF, 3.77 MB

english, 1989

5

Insulin-like growth factor receptor type I as a target for cancer therapy

Goetsch, Liliane, Corvaïa, Nathalie

Journal:

Year:

2009

Language:

english

File:

PDF, 1.51 MB

english, 2009

6

Time Resolved Native Ion-Mobility Mass Spectrometry to Monitor Dynamics of IgG4 Fab Arm Exchange and “Bispecific” Monoclonal Antibody Formation

Debaene, François, Wagner-Rousset, Elsa, Colas, Olivier, Ayoub, Daniel, Corvaïa, Nathalie, Van Dorsselaer, Alain, Beck, Alain, Cianférani, Sarah

Journal:

Analytical Chemistry

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

7

Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC–MS analysis

Janin-Bussat, Marie-Claire, Dillenbourg, Marina, Corvaia, Nathalie, Beck, Alain, Klinguer-Hamour, Christine

Journal:

Journal of Chromatography B

Year:

2015

Language:

english

File:

PDF, 408 KB

english, 2015

8

Tetraspanin CD151 as a target for antibody-based cancer immunotherapy

Haeuw, Jean‑François, Goetsch, Liliane, Bailly, Christian, Corvaia, Nathalie

Journal:

Biochemical Society Transactions

Year:

2011

Language:

english

File:

PDF, 408 KB

english, 2011

9

Selective induction of autocytotoxic activity through the CD3 molecule

Armand Bensussan, Gérald Leca, Nathalie Corvaïa, Laurence Boumsell

Journal:

European Journal of Immunology

Year:

1990

Language:

english

File:

PDF, 526 KB

english, 1990

10

Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways

Claire Bihoreau, Agnès Heurtier, Alain Enjalbert, Nicole Corvaïa, Armand Bensussan, Laurent Degos, Claude Kordon

Journal:

European Journal of Immunology

Year:

1991

Language:

english

File:

PDF, 655 KB

english, 1991

11

Modulation of Fcγ receptor-mediated early events by the tyrosine phosphatase CD45 in primary human monocytes. Consequences for interleukin-6 production

Nathalie Corvaïa, Ilona G. Reischl, Elisabeth Kroemer, Geert C. Mudde

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 790 KB

english, 1995

12

A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts

Liliane Goetsch, Alexandra Gonzalez, Olivier Leger, Alain Beck, Petrus J. Pauwels, Jean François Haeuw, Nathalie Corvaia

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 959 KB

english, 2005

13

Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor

Matthieu Broussas, Joëlle Dupont, Alexandra Gonzalez, Aline Blaecke, Mathilde Fournier, Nathalie Corvaïa, Liliane Goetsch

Journal:

International Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

14

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

Josef Vlasak, Marie C. Bussat, Shiyi Wang, Elsa Wagner-Rousset, Mark Schaefer, Christine Klinguer-Hamour, Marc Kirchmeier, Nathalie Corvaïa, Roxana Ionescu, Alain Beck

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 543 KB

english, 2009

15

Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells

Alain Beck, Marie-Claire Bussat, Nathalie Zorn, Virginie Robillard, Christine Klinguer-Hamour, Stéphane Chenu, Liliane Goetsch, Nathalie Corvaïa, Alain Van Dorsselaer, Jean-François Haeuw

Journal:

Journal of Chromatography B

Year:

2005

Language:

english

File:

PDF, 603 KB

english, 2005

16

The way forward, enhanced characterization of therapeutic antibody glycosylation: Comparison of three level mass spectrometry-based strategies

Elsa Wagner-Rousset, Audrey Bednarczyk, Marie-Claire Bussat, Olivier Colas, Nathalie Corvaïa, Christine Schaeffer, Alain Van Dorsselaer, Alain Beck

Journal:

Journal of Chromatography B

Year:

2008

Language:

english

File:

PDF, 2.01 MB

english, 2008

17

Synthesis and characterization of Respiratory Syncytial Virus protein G related peptides containing two disulfide bridges

A. Beck, M.C. Bussat, J.F. Haeuw, N. Corvaïa, T.N. Nguyen, J.Y. Bonnefoy, N. Zorn, A. Van Doersselaer

Journal:

Chemical Biology & Drug Design

Year:

2000

Language:

english

File:

PDF, 310 KB

english, 2000

18

Stability and CTL activity of N-terminal glutamic acid containing peptides

A. Beck, M.-C. Bussat, C. Klinguer-Hamour, L. Goetsch, J.-P. Aubry, T. Champion, E. Julien, J.-F. Haeuw, J.-Y. Bonnefoy, N. Corvaia

Journal:

Chemical Biology & Drug Design

Year:

2001

Language:

english

File:

PDF, 240 KB

english, 2001

19

Structure−antigenicity relationship studies of the central conserved region of human respiratory syncytial virus protein G

M. Sugawara, J. Czaplicki, J. Ferrage, A. Milon, J.-F. Haeuw, U. F. Power, N. Corvaïa, T. Nguyen, A. Beck

Journal:

Chemical Biology & Drug Design

Year:

2002

Language:

english

File:

PDF, 260 KB

english, 2002

20

Function and regulation of FcεRI expression on monocytes from non-atopic donors

I. G. REISCHL, N. CORVAÍA, F. EFFENBERGER, B. WOEFF-WINISKI, E. KRÖMER, G. C. MUDDE

Journal:

Clinical & Experimental Allergy

Year:

1996

Language:

english

File:

PDF, 5.27 MB

english, 1996

21

Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy

Tosch, C, Geist, M, Ledoux, C, Ziller-Remi, C, Paul, S, Erbs, P, Corvaia, N, Von Hoegen, P, Balloul, J-M, Haegel, H

Journal:

Cancer Gene Therapy

Year:

2008

Language:

english

File:

PDF, 336 KB

english, 2008

22

Antigen presentation in allergic sensitization

Mudde, Geert C, Reischl, Ilona G, Corvaïa, Nathalie, Hren, Andrea, Poellabauer, Eva-Maria

Journal:

Immunology & Cell Biology

Year:

1996

Language:

english

File:

PDF, 3.66 MB

english, 1996

23

Proliferation of resting lymphocytes is induced by triggering T cells through an epitope common to the three CD18/CD11 leukocyte adhesion molecules

Violaine David, Gerald Leca, Nathalie Corvaia, Francoise le Deist, Laurence Boumsell, Armand Bensussan

Journal:

Cellular Immunology

Year:

1991

Language:

english

File:

PDF, 1.07 MB

english, 1991

24

The immunodominant influenza matrix t cell epitope recognized in human induces influenza protection in HLA-A2/Kb transgenic mice

H. Plotnicky, D. Cyblat-Chanal, J.-P. Aubry, F. Derouet, C. Klinguer-Hamour, A. Beck, J.-Y. Bonnefoy, N. Corvaïa

Journal:

Year:

2003

Language:

english

File:

PDF, 234 KB

english, 2003

25

Outer membrane protein A (OmpA) activates human epidermal Langerhans cells

Sylvie Godefroy, Nathalie Corvaia, Daniel Schmitt, Jean-Pierre Aubry, Jean-Yves Bonnefoy, Pascale Jeannin, Marie-Jeanne Staquet

Journal:

European Journal of Cell Biology

Year:

2003

Language:

english

File:

PDF, 322 KB

english, 2003

26

Bradykinin Induces Tyrosine Phosphorylation of Epidermal Growth Factor-Receptor and Focal Adhesion Proteins in Human Keratinocytes

K.D. Coutant, N. Corvaia, N.S. Ryder

Journal:

Biochemical and Biophysical Research Communications

Year:

1995

File:

PDF, 394 KB

1995

27

Functional responses and in vivo anti-tumour activity of h7C10: A humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors

Giuseppe Pandini, Thierry Wurch, Barbara Akla, Nathalie Corvaia, Antonino Belfiore, Liliane Goetsch

Journal:

European Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 425 KB

english, 2007

28

P40: a promising new carrier protein

I. Rauly, L. Goestch, C. Libon, A. Beck, J.F. Haeuw, T.N. Guyen, T. Baussant, J.Y. Bonnefoy, N. Corvaia

Journal:

Research in Immunology

Year:

1998

Language:

english

File:

PDF, 88 KB

english, 1998

29

Mitogenic effect and activation of HIV1 production in serotonin-treated peripheral blood mononuclear cells derived from infected patients

S. Sidibé, F. Saal, N. Corvaïa, A. Rhodes-Feuillette, M. Canivet, J. Peries, L. Dianoux

Journal:

Research in Virology

Year:

1997

Language:

english

File:

PDF, 355 KB

english, 1997

30

286 Generation of a recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) with an antitumor activity in a variety of human cancer xenograft models

I. Goetsch, A. Gonzalez, A. Beck, J.F. Haeuw, N. Corvaia

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 288 KB

english, 2004

31

120 POSTER Transduction of tumor cell lines with adenoviral vectors expressing TLR ligands and scFv anti-IL-10 activates dendritic cell maturation and IL-12 secretion in the presence of IL-10

H. Haegel, M. Geist, N. Corvaia, C. Tosch

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 147 KB

english, 2006

32

195 POSTER In vitro and in vivo inhibition of functional responses at insulin-like growth factor-1/insulin hybrid receptors by h7C10, a novel humanized anti-IGF-1R monoclonal antibody

T. Wurch, G. Pandini, B. Akla, N. Corvaia, A. Belfiore, L. Goetsch

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 56 KB

english, 2006

33

522 POSTER Discovery of the 6F4 anti-tumor antibody targeting the tight junction molecule JAM-A. 1. Target identification by proteomic approach

J.F. Haeuw, L. Goetsch, L. Zanna, M. Malissard, V. Robillard, A.M. Lepecquet, A. Robert, C. Bailly, N. Corvaïa

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 92 KB

english, 2008

34

544 POSTER Discovery of the 6F4 anti-tumor antibody targeting the tight junction molecule JAM-A. 2. Target expression on human tumors and in vitro and in vivo anti-cancer activity

L. Goetsch, J.F. Haeuw, A. Gonzalez, C. Beau-Larvor, L. Zanna, T. Wurch, C. Bailly, N. Corvaïa

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 69 KB

english, 2008

35

241 515H7, a novel anti-CXCR4 antibody - Part I: in vitro efficacy on CXCR4-associated signaling pathways

T. Wurch, N. Boute, S. Bernois, C. Bertaux, C. Beau-Larvor, L. Troncy, C. Bailly, N. Corvaia, C. Klinguer-Hamour

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 46 KB

english, 2010

36

225 515H7, a novel anti-chemokine receptor 4 (CXCR4) antibody. Part II: in vivo efficacy on CXCR4-dependent tumor models

C. Klinguer-Hamour, F. Geronimi, B. Akla, A. Robert, C. Tardy, A. Gerentet-de-Saluneaux, J.F. Haeuw, C. Bailly, L. Goetsch, N. Corvaia

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

37

Synthesis, refolding and protective immune responses of a potential antigen for human Respiratory Syncytial Virus vaccine

C. Klinguer-Hamour, M.-C. Bussat, H. Plotnicky, D. Velin, N. Corvaïa, T. Nguyen, A. Beck

Journal:

European Journal of Allergy and Clinical Immunology

Year:

2003

Language:

english

File:

PDF, 242 KB

english, 2003

38

005 Interactions épithélium bronchique /cellules dendritiques et conséquences sur l’orientation de la réponse lymphocytaire t : modulation par KpOmpA

Pichavant, M., Taront, S., Jeannin, P., Charbonnier, A.-S., Fourneau, C., Corvaia, N., Heliot, L., Brichet, A., Tonnel, A.-B., Delneste, Y.

Journal:

Revue des Maladies Respiratoires

Year:

2006

Language:

french

File:

PDF, 82 KB

french, 2006

39

Solvent Polarity and pH Effects on the Magnetic Properties of Ionizable Nitroxide Radicals: A Combined Computational and Experimental Study of 2,2,5,5-Tetramethyl-3-carboxypyrrolidine and 2,2,6,6-Tetramethyl-4-carboxypiperidine Nitroxides

Saracino, Gloria A. A., Tedeschi, Annamaria, D'Errico, Gerardino, Improta, Roberto, Franco, Lorenzo, Ruzzi, Marco, Corvaia, Carlo, Barone, Vincenzo

Journal:

Journal of Physical Chemistry A

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

40

Innovative Native MS Methodologies for Antibody Drug Conjugate Characterization: High Resolution Native MS and IM-MS for Average DAR and DAR Distribution Assessment

Debaene, François, Bœuf, Amandine, Wagner-Rousset, Elsa, Colas, Olivier, Ayoub, Daniel, Corvaïa, Nathalie, Van Dorsselaer, Alain, Beck, Alain, Cianférani, Sarah

Journal:

Analytical Chemistry

Year:

2014

Language:

english

File:

PDF, 2.45 MB

english, 2014

41

113 Preclinical activity and pharmacodynamic biomarkers of W014A, a PD-1 decoy peptide blocking both PD-1 immune checkpoint ligands, PD-L1 and PD-L2

Bailly, C., Broussas, M., Ramachandra, M., Sasikumar, P.G., Shrimali, K., Adurthi, S., Ramachandra, M., Satyam, L.K., Dhudashia, A.A., Dhodheri, S., Sunilkumar, K.B., Corvaïa, N., Ferre, P.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 61 KB

english, 2014

42

351 hz515H7, a humanized antibody exerts its antitumor activity via antagonism of the CXCR4/SDF-1 axis, and through effector functions

Klinguer-Hamour, C., Broussas, M., Akla, B., Berger, S., Boute, N., Beau-Larvor, C., Robert, A., Haeuw, J.F., Goetsch, L., Bailly, C., Corvaia, N.

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 60 KB

english, 2014

43

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

Marcoux, Julien, Champion, Thierry, Colas, Olivier, Wagner-Rousset, Elsa, Corvaïa, Nathalie, Van Dorsselaer, Alain, Beck, Alain, Cianférani, Sarah

Journal:

Protein Science

Year:

2015

Language:

english

File:

PDF, 1.82 MB

english, 2015

44

Complement Dependent Amplification of the Innate Response to a Cognate Microbial Ligand by the Long Pentraxin PTX3

Cotena, A., Maina, V., Sironi, M., Bottazzi, B., Jeannin, P., Vecchi, A., Corvaia, N., Daha, M. R., Mantovani, A., Garlanda, C.

Journal:

The Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 456 KB

english, 2007

45

Impact of Bronchial Epithelium on Dendritic Cell Migration and Function: Modulation by the Bacterial Motif KpOmpA

Pichavant, M., Taront, S., Jeannin, P., Breuilh, L., Charbonnier, A.-S., Spriet, C., Fourneau, C., Corvaia, N., Heliot, L., Brichet, A., Tonnel, A.-B., Delneste, Y., Gosset, P.

Journal:

The Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 708 KB

english, 2006

46

Identification of B- and T-Cell Epitopes of BB, a Carrier Protein Derived from the G Protein of Streptococcus Strain G148

Goetsch, L., Haeuw, J. F., Champion, T., Lacheny, C., N'Guyen, T., Beck, A., Corvaia, N.

Journal:

Clinical and Vaccine Immunology

Year:

2003

Language:

english

File:

PDF, 1.33 MB

english, 2003

47

Gamma Interferon-Dependent Protection of the Mouse Upper Respiratory Tract following Parenteral Immunization with a Respiratory Syncytial Virus G Protein Fragment

Plotnicky-Gilquin, H., Cyblat-Chanal, D., Aubry, J.-P., Champion, T., Beck, A., Nguyen, T., Bonnefoy, J.-Y., Corvaia, N.

Journal:

Journal of Virology

Year:

2002

Language:

english

File:

PDF, 385 KB

english, 2002

48

Challenge of BALB/c Mice with Respiratory Syncytial Virus Does Not Enhance the Th2 Pathway Induced after Immunization with a Recombinant G Fusion Protein, BBG2NA, in Aluminum Hydroxide

Corvaïa, Nathalie, Tournier, Patricia, Nguyen, Thien Ngoc, Haeuw, Jean François, Power, Ultan F., Binz, Hans, Andréoni, Christine

Journal:

The Journal of Infectious Diseases

Year:

1997

Language:

english

File:

PDF, 196 KB

english, 1997

49

Safety and Immunogenicity of a Novel Recombinant Subunit Respiratory Syncytial Virus Vaccine (BBG2Na) in Healthy Young Adults

Power, Ultan F., Nguyen, Thien N., Rietveld, Edwin, de Swart, Rik L., Groen, Jan, Osterhaus, Albert D. M. E., de Groot, Ronald, Corvaia, Nathalie, Beck, Alain, Bouveret‐le‐Cam, Nancy, Bonnefoy, Jean‐Y

Journal:

The Journal of Infectious Diseases

Year:

2001

Language:

english

File:

PDF, 63 KB

english, 2001

50

Targeting of Nasal Mucosa-Associated Antigen-Presenting Cells In Vivo with an Outer Membrane Protein A Derived from Klebsiella pneumoniae

Goetsch, L., Gonzalez, A., Plotnicky-Gilquin, H., Haeuw, J. F., Aubry, J. P., Beck, A., Bonnefoy, J. Y., Corvaia, N.

Journal:

Infection and Immunity

Year:

2001

Language:

english

File:

PDF, 824 KB

english, 2001

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